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Description
This intermediate promptly reacts with triplet oxygen ( 3 O 2 ) to form an oxygenated complex (Cyt P 450 -ROO )
Gen Comp Endocrinol (1984) 56:33348
In general, both generate a unique chromosomal chemical modification for each parent, leading to different expressions of genes located on these chromosomes
Epalrestat restored the chemosensitivity of lung cancer cells resistant to epidermal growth factor receptor (EGFR), and tyrosine kinase inhibitor (TKI), in addition to delaying resistance in a murine lung cancer xenograft model [157]
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This same model can be translated to a growing mass of tumor cells whereby ADCC acts to wipe out a growing malignancy (56)
