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Following injury induction (a 0.8 centimeter osteoperiosteal defect was created in the middle of both radii), the experiments using bone marrow and the TRIS-BPC157 (6 rabbits per group) were carried out as follows: Saline (2 ml intramuscularly and 2 ml locally into each of the bone defects) treated injured animals were used as controls (group 1)

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The antinociceptive action of speciociliatine, 7-hydroxymitragynine, mitragynine, and morphine were fully antagonized by naltrexone (0.1 mg/kg, i.v.)

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