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57% had stable or improved EDSS scores (change 0.5 or fewer points)

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The non-chelatable iron pool is sequestered in ferritin and in specific proteins [e.g., heme and ironsulfur complexes (ISCs)] as an structural component, and therefore this iron pool cannot be removed by conventional iron chelators, like desferal

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Medicina (Kaunas) 57(9):893

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Exhausted T cells show a reduced capacity to perform metabolic processes such as aerobic glycolysis and oxidative phosphorylation (OXPHOS), both due to external influences and intrinsic signals, such as PD-1 expression (136)

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R.PopM.DeboyR

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Glutaredoxins and iron-sulfur protein biogenesis at the interface of redox biology and iron metabolism

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