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407 Additionally, researchers have found that incorporating siRNA into PEG-modified polylysine with cRGD can enhance gene silencing ability, improve cell uptake, inhibit glioma angiogenesis, and delay tumor progression after systemic administration in mice

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by exploiting thiol groups on cysteine amino acids and unsaturated carbon bonds of functionalities introduced to PEG (norbornene, acrylate, etc.), peptides can be incorporated into hydrogels as crosslinking agents or tethered pendant groups (Fairbanks et al., 2009
