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18 VenketaramanV.RodgersT.LinaresR.ReillyN.SwaminathanS.HomD.et al (2006)

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Amylin analogs may offer innovative approaches to enhance metabolic and cardiovascular health, potentially reducing the global burden of cardiovascular diseases 5

Cytoplasmic malate dehydrogenase (encoded by the MDH1 gene) reduces oxaloacetate (OAA) to malate while oxidizing NADH to NAD +

By employing a -adrenergic receptor blocker and a ghrelin receptor antagonist, they discovered that the oral intake of hydrogen water activates the -adrenergic receptor signaling pathway in the stomach, inducing ghrelin secretion, which in turn protects dopaminergic neurons in MPTP-induced PD model mice