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The EFSA notes, The inherent uncertainty of this [factorial] approach is reflected in the wide range of cobalamin intake calculated to compensate for estimated daily losses, depending on the assumptions taken (EFSA, 2015). Appendix D

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This reduced vascular flow means fewer healing nutrients reach damaged tissue

Common lab protocols involve reconstitution in bacteriostatic water and subcutaneous injection in animal models using calibrated syringes to achieve precise dosing

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