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The elevated macrocytic index and the dietary history were the diagnostic clues in this patient

The results showed that cellular ALP content was increased, PGE2 and NO content was decreased and OPG, Wnt1 and p--catenin protein expression levels were upregulated, whereas RANKL protein expression levels were downregulated

doi: 10.1186/1742-2094-11-59
A subsequent isolation and amino acid sequence determination of two homogeneous polypeptides from purified non-suppressible insulin-like activity factors (158160) established the current designation of these molecules as insulin-like growth factors (IGFs) 1 and 2 (161)

Chtel, H

Perspectives on oxidative stress in Alzheimers disease and predictions of future research emphases
