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The placenta experiences a heightened level of OS in certain pathologic conditions of pregnancies, including gestational diabetes, fetal growth restriction, preeclampsia and miscarriage [64,65,66]

Similarly, the SH-SY5Y neuroblastoma cell line, commonly used for in vitro PD studies, lacks the complete neuronal and glial cell interactions present in vivo and may not fully represent primary dopaminergic neurons responses, reducing translational relevance of findings

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