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Briefly, MDA-MB-231 cells were continuously treated with increasing concentrations of cDDP (up to a maximum of 2 M) during 6 months

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Neuropsychobiology 36:211214 Kunz D, Bes F (1999) Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation

Under conditions where oxygen availability becomes limiting (e.g., ischemia or possibly exercise-associated hypoxia), this metabolic shift optimizes cellular energy production