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This exacerbates mitochondrial dysfunction, creating a vicious cycle where mitochondrial impairment leads to further increased ROS production and aggravated oxidative stress [7]
Song et al., 2019)

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Peroxynitrite nitrates tyrosine residues in proteins and increased nitrotyrosine is increased in induced sputum and lungs of patients with COPD [41,42]

Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis
