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This observation has been reported in earlier studies in obese and hyperinsulinemic subjects, and in patients with Cushings syndrome, in whom hepatic sensitivity to GH is increased when compared to lean subjects (95, 103)

doi: 10.15252/embj.2020105802

While the impact of OTA appears to be related to its concentration in the kidney, sufficiently high levels of OTA will cause oxidant damage in any organ tissue [79]

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