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Accepted: April 9, 2019
For example, cis-3-(9H-purin-6-ylthio)acrylic acid (PTA) is a prodrug of the antitumor and immunosuppressive antimetabolite 6-mercaptopurine that requires GSH conjugation and subsequent metabolism for activation (Gunnarsdottir and Elfarra, 1999)
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Another perk of this ingredient is that it stays functional across a wide pH range (3-10)
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