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In pancreatic ductal adenocarcinoma (PDAC), tumor-intrinsic factors, notably KRAS mutation status, and iatrogenic influences like chemotherapy-induced dysbiosis, dramatically reshape BA profiles and modulate the local TIME (160)

Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production

Developing more accurate and representative experimental platforms, such as patient-derived organoids or sophisticated immune-competent animal models, is essential for translating laboratory discoveries into effective clinical interventions

Even with the evolution of preventive vaccines and medicine, persistent and prolonged effects after acute COVID-19 have debilitated millions of subjects worldwide

doi: 10.1016/j.neurobiolaging.2008.07.004