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The likelihood of developing peripheral neuropathy increases with multiple treatment courses, use of combination chemotherapy and higher doses

doi: 10.1016/j.clnu.2015.01.020

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Meanwhile, Akt activity is inhibited, accompanied by downstream activation of GSK3 and subsequent excessive phosphorylation of tau protein, forming a cascade of oxidative stress-IR-A/tau pathology, thereby accelerating AD progression [90, 91] (Fig

PMID: 10582122