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However, there was a significant reduction in severe PVH (grade 3 and 4) in some studies (114)

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[1] [4] When B12 is deficient, myelin production is impaired, leading to demyelinationthe breakdown of this protective sheathwhich results in abnormal nerve signalling perceived as pain, tingling, or numbness

10.1016/j.neuroscience.2017.01.025 [DOI] [PMC free article] [PubMed] [Google Scholar] 216.Feng S, Liu J, Cheng B, Deng A, Zhang H