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Aging is a physiological process that includes a gradual decrease in skeletal muscle mass, strength, and endurance, coupled with an ineffective response to tissue damage [35]

Down-regulation of TMAO levels by dimethyl-1-butanol (DMB), a TMA formation inhibitor, is able to ameliorate the cognitive deterioration and long-term potentiation (LTP) in APP/PS1 mice and decrease amyloid- (A)1-42, -secretase, and -secretase-cleaved C-terminal fragment (CTF) levels in the hippocampus (Morello et al., 2000)