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Nevertheless, attempts to develop melatonin as a contraceptive pill in combination with progestin have not been successful (58)

As you can see in the equation above its also related to the pH of the solvent

Selective Adamax Adamax (N-Acetyl Semax Adamantane, CHNOS, MW ~1,032 Da, CAS AOD9604 AOD9604 (CHNOS, 16aa C-terminal fragment of GH residues 177-191 BPC-157 BPC-157 (CHNO, 15aa pentadecapeptide, MW ~1,420 Da, CAS 137525-51-0)

Experiments were performed at least three times with at least three technical replicates in each experiment

Some specific short-term protocols even use up to 2000 mg without significant adverse effects

PMC 5390862