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However, their application is limited by nonspecific toxicity

Decades of work on the effects of oxidative stress on lens proteins have built on the seminal work of Antoinette Pirie, 14 , 15 and Ruth van Heyningen 16 , and colleagues, 17 Working at the Nuffield Laboratory of Ophthalmology, Oxford University in the 1960s and 1970s, they demonstrated that exposure of lens protein solutions to sunlight caused the proteins to become heavily pigmented, to cross-link, and to aggregate

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Mol Psychiatry 27:50495061 Bot M, Milaneschi Y, Al-Shehri T, Amin N, Garmaeva S, Onderwater GLJ, Pool R, Thesing CS, Vijfhuizen LS, Vogelzangs N, Arts ICW, Demirkan A, van Duijn C, van Greevenbroek M, van der Kallen CJH, Kohler S, Ligthart L, van den Maagdenberg A, Mook-Kanamori DO, de Mutsert R, Tiemeier H, Schram MT, Stehouwer CDA, Terwindt GM, Willems van Dijk K, Fu J, Zhernakova A, Beekman M, Slagboom PE, Boomsma DI, Penninx B, Consortium B-NM (2020) Metabolomics profile in depression: a pooled analysis of 230 metabolic markers in 5283 cases with depression and 10,145 controls