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Ongoing human research, such as the ClinicalTrials.gov study on MOTS-C and insulin sensitivity , is evaluating these mechanisms in adults with metabolic risk factors
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10.1016/S1470-2045(17)30865-3 8
[PubMed Citation] Borgstrm L, Kgedal B, Paulsen O
These agents in fact reacted adversely with cysteinyl residues in topoisomerase by using mutant yeast TOP2 with all cysteine residues replaced with alanine (cysteineless TOP2)
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