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Excess GLU-derived -KG is converted to ICT by IDH2, with concomitant oxidation of NADPH to NADP +

discovered that by increasing the antioxidant level and free radical scavenging enzyme system, Que could reduce the level of ROS and subsequent lipid peroxidation in the hippocampus

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Individual responses may vary, and more research is needed to fully understand the extent of TB-500's potential benefits

Chest 2014;146:11141122

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