glutathione synthesis definition Frontiers Figure 2 from GLUTATHIONE SYNTHESIS
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Thus, the depletion of TH in the SN is not the primary event in the pathogenesis of PD

According to the EORS theory, aging is associated with sedentary behavior, which leads to an oxidized redox shift characterized by an extracellular decrease in the ratio of cysteine to cystine and an intracellular decrease in the ratio of GSH to GSSG and NAD(P)H to NAD(P) (419)
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Leydig cell aging and the mechanisms of reduced testosterone synthesis

Wu, C., Martel, D

It's not a simple question, and the answer is far more nuanced than a single spot on a diagram
