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Zhang X, Yin G, Chen S, et al

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This methodology presents an issue with linking mechanistic actions of endocrine disrupting chemicals to the risk of disease development since endocrine dysfunction, especially within estrogenic pathways (e.g., menopausal status, menstrual cycle length, early menarche, and contraception use), are typically associated with reasons for hysterectomy (Upson and Missmer, 2020)

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In the MMR-D cohort, 12-month PFS was 63.5%, compared to 24.4% in the placebo arm, and 24-month PFS was 61.4%, compared to 15.7% in the placebo arm, HR 0.28 (95% CI 0.160.50)

Available online: 142.Kroeger P.T., Jr., Drapkin R