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During adolescence, high insulin levels caused by IR may disrupt the gonadotropin-releasing hormone (GnRH) signaling pathway and induce HA through multiple pathways, thereby affecting the establishment of ovulatory function

Modified oxidative lipid metabolism and dysregulated iron homeostasis have been implicated in the pathogenesis of this disorder, but the detailed pathophysiological mechanisms still remain unclear

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As a bioactive agent, salicylic acid has inspired several research groups to explore its potential beneficial effects on heat tolerance

No changes in fasting glucose, insulin, HbA1c, IGF-1, cortisol, or thyroid hormones were detected at any dose tested