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Description
The Reversible Increase in Tight Junction Permeability Induced by Capsaicin Is Mediated via Cofilin-Actin Cytoskeletal Dynamics and Decreased Level of Occludin
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11 AvolioE.OlivitoI.RosinaE.RomanoL.AngeloneT.De BartoloA.et al (2022)
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It functions as a cytosolic second messenger by binding to Ins(1,4,5)P 3 receptors, which are located on the endoplasmic reticulum membrane and operate as ER Ca 2+ release channels
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Excessive iron supply triggered the activation of NADPH oxidase 4 (NOX4), leading to excessive H2O2 and lipid peroxide production
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