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Methotrexate is our first-line treatment for rheumatoid arthritis, says Francesca Okoye, MD, a board-certified rheumatologist with Rheumatology at Mercy Medical Center in Baltimore, Maryland

Additional proposed mechanisms include interaction with NMDA receptors and modulation of the stress and HPA axis , the hypothalamic-pituitary-adrenal system that governs the body's stress response

While the ongoing SURPASS clinical trial aims to elucidate the mechanistic underpinnings of the drug and the best dosages for treating patients of varying BMIs, its benefits cannot be understated

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