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Similar content being viewed by others Introduction Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic disorder characterized by pain, unpleasant pressure, or discomfort in the lower pelvis area 1,2,3,4,5

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In rare cases, it may cause joint pain or muscle stiffness due to increased growth hormone levels

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It has been shown that donepezil can protect against oxidative stress and mitochondrial function deficiency, reduce the apoptotic ratio of Bax/Bcl-2 and cleaved-caspase 3/caspase 3, and protect against receptor-interacting protein kinase 1-mediated necrosis of cardiomyocytes caused by adriamycin by activating the muscarinic ACh receptor (112)

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