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This research is still in early stages, but the combination of topical convenience, rapid onset, steroid-comparable efficacy, and systemic immune modulation makes PEPITEM-derived tripeptides one of the most exciting developments in psoriasis peptide research

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The intracellular concentrations of vitamin B12 can be inferred through the total plasma concentration of homocysteine, which can be converted to methionine through an enzymatic reaction that uses 5-methyltetrahydrofolate as the methyl donor group

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By attaching a larger molecule, like a polyethylene glycol (PEG) chain (a process called PEGylation), scientists can make the peptide too large to be easily filtered by the kidneys and can also sterically hinder the approach of degrading enzymes

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