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Studies on rat testis presented that, in addition to spermatogenic cells, the quantity of supporting Sertoli and Leydig cells declined significantly in the rats exposed to busulfan in comparison with the control group

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2024;13:e98096

Therefore, this comprehensive review aims to provide an up-to-date critical overview on cereblon-based PROTACs, covering the main aspects related to the chemical synthesis of cereblon ligands derivatives, the chemical ligation of these derivatives to the linkers, and the construction of the final cereblon PROTAC