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Activation of the somatostatin receptor 3 (SSTR3) leads to its arrestin-dependent ubiquitination and subsequent exit (Shinde et al., 2020) while constitutive ubiquitination of SMO by the ligase WWP1 keeps ciliary SMO levels low under basal conditions (Lv et al., 2021)

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Jelovac N, Sikiric P, Rucman R, et al

[118] reported that indigenous Isfahan chickens displayed stronger induction of heat shock proteins, whereas commercial Ross broilers exhibited greater upregulation of innate immune genes such as TLR4 and IL4I1 , indicating divergent genetic strategies for coping with thermal stress