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Epigenetic modifications, such as mtDNA hypermethylation, impair mitochondrial gene expression and respiration, while decreased SIRT3 activity contributes to the loss of redox homeostasis in retinal endothelial cells (18)
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Over time, it has expanded into functional and integrative medicine as part of comprehensive detoxification protocols
Interestingly, in rodent models, puberty-induced hormonal changes result in a less diverse gut microbiome in males compared to females [123]
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