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Description
Carfilzomib is formulated with SBE--CD as an inclusion complex in Kyprolis , a powder for solution for infusion, in order to improve aqueous solubility [112]
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The absence of large-scale safety data becomes grounds for dismissal, prohibition, or silence
One example escalation schedule observed in Phase 2 obesity trials proceeded broadly as follows: Weeks 14: 2 mg once weekly (initiation phase) Weeks 58: 4 mg once weekly Weeks 912: 8 mg once weekly Weeks 13 onwards: Up to 12 mg once weekly (the maximum dose explored in Phase 2 trials) This is an illustrative example only
Overexpression of GSTs may contribute to increase detoxification of anticancer drugs 68
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