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FDA has issued several nanotechnology guidance documents emphasizing material characterization, critical quality attributes, and risk-based assessment, while the EMA provides more structured guidance for nanocarriers and liposomal products, including scientific advice for nanoparticle excipients and surface modifications

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Introduction The Blood Brain Barrier The term bloodbrain barrier (BBB) was used to describe the unique characteristics of the microvasculature of the central nervous system (CNS)