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Bradley JL, Homayoun S, Hart PE et al (2004) Role of oxidative damage in Friedreichs ataxia

Functional deficiency of astrocytic glutamate clearance and K + buffering is the primary cause of neuronal damage in neurodegenerative diseases, most notably in amyotrophic lateral sclerosis (ALS) and Huntingtons disease (HD) 148,149,150,151,152,153 , whereas functional asthenia of astrocytes may exacerbate -amyloid pathology in the context of Alzheimers disease (AD) 154

Athira is performing four clinical trials on a compound called fosgonimeton (also called ATH-1017) for neurological conditions, including Alzheimers disease
XW: Conceptualization, Writing original draft, Writing review and editing

S., Heuman D
doi: 10.1016/J.IMMUNI.2018.05.005 161 KiernanKMacIverNJ
