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Thus, k obs is one half of the limiting rate constant at the pK a , but falls to 1/10 4 of the maximal reactivity at 4 pH units below the pK a

doi: 10.1007/s12032-021-01586-8 [DOI] [PubMed] [Google Scholar] 45.Fu J, Zeng W, Chen M, et al

Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth

Emerging mechanistic insights into AAA complexes regulating proteasomal degradation

Early studies (1960s-1990s) established a preliminary link between DNA repair defects and human diseases by observing syndromes such as xeroderma pigmentosum, and also revealed evidence of genomic instability in patients with SLE and other autoimmune conditions (38-41)

Therefore, the genes response pattern to various stress factors has been the subject of extensive research [24,25,26]
