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In the susceptible ecotype the induction of these defense-related genes was clearly delayed as compared to the resistant one (Ho and Yang, 1999)

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A phase II study of the HDAC inhibitor givinostat in combination with hydroxyurea in patients with polycythemia vera resistant to hydroxyurea monotherapy

In Parkinsons disease, curcumin inhibits DNMTs, leading to demethylation and reactivation of neuroprotective genes like Nurr1, DJ-1, and PARK genes, and acts as an HDAC inhibitor to enhance histone acetylation, promoting transcription of genes involved in neuronal survival and synaptic plasticity