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Use of ozone therapy in diabetic foot ulcers

References 1 Khavinson V.Kh

When two or more dimensions shift toward a pro-oxidative state, such as reduced DHODH activity due to POLQ or E2F4 inhibition, D-lactic acid accumulation triggered by CDK7-YAP-LDHD pathway disruption, or CD8 + IFN- silencing of SLC7A11, CSCs lose self-renewal capacity and become susceptible to ferroptosis

The therapeutic effect of rilotumumab in CRC has also been evaluated in a randomized phase Ib/II research where panitumumab (a monoclonal antibody targeting EGFR) was combined with rilotumumab or placebo in patients with kirsten rat sarcoma (KRAS) wild-type metastatic CRC who met the prespecified criterion for improvement in ORR (Van Cutsem et al., 2014)