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Especially when the alternative carries side effects that push plenty of users to quit

(PubMed) National Center for Environmental Health

Under acute hypobaric hypoxia, the body adapts to the external environment by changing a series of gene expressions, and hypoxia inducible factor-1 (HIF-1) is the most important transcription factor that regulates cellular adaptation to hypoxia, which plays a key role in cellular perception and acclimatation to the change of oxygen concentration (Li et al., 2020a)

Implications in practice As there is no apparent clinical significance, the treatment should depend on the patients condition