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Tirzepatide activates both of these receptor pathways simultaneously, which is why researchers and clinicians often describe it as a "twincretin." The appetite suppression effect is profound

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Given the ability of tesofensine to modulate the activity of the LH, our preclinical findings agree with the proposal that tesofensine could be a useful treatment for patients with hypothalamic obesity, a rare feeding disorder, as recently demonstrated [38]

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