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Description

Nevertheless, pyridoxal phosphate and pyridoxamine phosphate are the active endogenous metabolites of vitamin B6 that are involved in various biochemical reactions, including the metabolism of macronutrients, synthesis of nucleic acids, hemoglobin, and neurotransmitters (52, 53)

In a systematic review of 5 studies including 95 patients, the efficacy and tolerability of 8% capsaicin patch was evaluated for its effectivess in mitigating the effects of chemotherapy-induced peripheral neuropathy, providing significant pain relief [101]

Animal studies have shown that even mild zinc deficiency impairs oocyte quality and fertilization

Ischemic lesions involving this region have been associated with an increased risk of cardiac complications ( Beyond autonomic regulation, the insula integrates autonomic, neuroendocrine, and inflammatory viscerosensory feedback into subjective emotional states (interoception) ( The medial prefrontal cortex, located in the medial frontal lobe, and orbitofrontal cortex, situated on the ventral surface of the frontal lobes, are involved in the cognitive appraisal and regulation of emotional responses