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Fracture non-union often results in devastating outcomes for the patient and the surgeon [2, 5, 6], requiring a complex, long-lasting and expensive treatment, and a variable degree of morbidity is often a common finding [2, 7, 8]

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For most responders, due to the failure of complete elimination of tumor cells, recurrence of tumors from the minimal residual diseases (MRD) are ultimately inevitable (Auberger et al., 2020

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Also, EpCAM plays an important role in the suppression of anti-tumor immunity
