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Although to date Aro10 has not been found to be stabilized upon deletion of any known GID E3 ligase substrate receptors 35,37 , our data reveal a correlation with Gid4-dependent regulation, and raise the possibility of yet additional forms of GID E3 ligase regulation to be discovered in future studies

Several types of CDs and CD-ligand conjugates have been reported successfully penetrating the BBB, which shows a promising progress in the application of CD-based drug delivery system (DDS) for the treatment of CNS diseases

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doi:10.1038/s41467-019-10807-8
Flint, D.H., Tuminello, J.F., and Emptage, M.H., The inactivation of Fe-S clusters containing hydro-lyases by superoxide, J
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