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First, animal experimental models are much more expensive and require many more resources than cellular models

Katsifis GE, Moutsopoulos NM, Wahl SM (2007) T lymphocytes in Sjgrens syndrome: contributors to and regulators of pathophysiology

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Using Polysomnogram these parameters are measured: Heart rate, airflow monitored by Side stream End-Tidal Capnography, which also provided breath-by-breath assessments of end-tidal carbon dioxide levels, nasal pressure, and an oronasal thermistor, were measured along with the chest and abdominal wall movements