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A recent meta-analysis of randomized controlled trials (n338) reported a statistically significant reduction in core ASD symptoms (standardized mean difference0.67) following KD interventions (Yu et al., 2022)

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(Level Ia, Grade A) Corneal confocal microscopy (CCM) is a noninvasive technique used to detect small nerve fiber loss in the cornea which correlates with both increasing neuropathic severity and reduced IENFD in diabetic patients 92;93