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Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded

Table D2: Suitability for Recreation Grade Matrix Notes: * Indicates unexpected results requiring investigation (reassess SIC and MAC)

[DOI] [PubMed] [Google Scholar] Frielle T, Collins S, Daniel KW, Caron MG, Lefkowitz RJ, Kobilka BK

The suitability of propofol compared with urethane for anesthesia during urodynamic studies in rats

Alcohol metabolism rapidly depletes the glutathione you just received, essentially undoing the infusion