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It usually affects one joint at a time (often the big toe joint)

[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Xia ML, Xie XH, Ding JH, Du RH, Hu G

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The Ohio native registered a five-under 66 in the opening round on Thursday behind six birdies, 11 pars and a bogey on the par-four fifth his second hole of the round
[Google Scholar] Peroxiredoxins: Yeast Redox Switches That Regulate Multiple Cellular Pathways