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In one study, overexpression of miR-378 in the mouse ovarian bursa led to a decrease in ovarian size and pups, illustrating this phenomenon [230]

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Similar to pharmacologic inhibition of GSH synthesis, loss of GCLC, the rate limiting enzyme of GSH synthesis, also strongly induced SLC25A39 protein (Fig

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All these effects were a result of cereblon-dependent degradation of CDK9 protein promoted by lenalidomide-based PROTAC L055 (Table 10) 148

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