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Bone Weakening: Prolonged periods of low estrogen can lead to reduced bone mineral density (osteopenia) and eventually osteoporosis, increasing the risk of fractures later in life

S2CID 1822164

Refrigeration at 28C slows these reactions dramatically but does not stop them entirely

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Insulin-like growth factor-1 and lipid metabolism IGF-1 promotes preadipocyte differentiation [181], however, as preadipocytes differentiate, they stop expressing IGF-1Rs, delegating such functions now to insulin receptors, which increase in number significantly

They produce more body heat relative to other animals because of their large muscle mass