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However, theres an important caveat: most of the data comes from animal research, not human clinical trials

For instance, female mice administered BSO exhibited much higher susceptibility to acetaminophen-induced hepatotoxicity than male mice [43], while male mice treated with BSO were much more susceptible to thiabendazole nephrotoxicity than females [44]

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Therefore, the fraction of drug that survives the first pass through the liver is simply (1 - E)

doi: 10.1016/j.brainres.2010.12.014 162