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Several studies have highlighted the potential use of ALA in diabetes, due to its ability to increasing both sugar uptake in insulin-sensitive and insulin-resistant muscle tissues [4,47], and to stimulate the glucose uptake by the repartition of glucose transporters to the plasma membrane, and tyrosine phosphorylation of insulin receptor substrate-1 [9]

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The point of this piece is to walk through the receptor-level reasoning underneath the cycling conversation so its clear which compounds in the research space genuinely require time off, which ones dont, and which ones fall into a third category where the break is about something else entirely