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In vitro experiments demonstrated that cancer-associated adipocytes upregulate the hexosamine biosynthetic pathway (HBP), leading to O-GlcNAcylation and stabilization of the YAP protein
Wallace DC, Ye JH, Neckelmann SN, Singh G, Webster KA, Greenberg BD
Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (83)
A., Galanski, M
The above research results confirm that TMAO plays a role in promoting the progression of OA
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